Patricia M. Nunes1,
Andor Veltien1, Henk Arnts2, Tineke van de Weijer3,
Patrick Shrauwen3, Cees J. Tack4, Arend Heerschap1
1Radiology, Radboud
University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Central
Animal Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen,
Netherlands; 3Human Biology, NUTRIM, School of Nutrition,
Toxicology & Metabolism,
Maastricht University Medical Centre, Maastricht, Netherlands; 4Internal
Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Absence of adipose-triglyceride-lipase(ATGL), mainly expressed in muscle and adipose tissue, leads to triglyceride accumulation and decreased free-fatty-acid availability, boosting glucose metabolism. Here, we tested muscle mitochondrial oxidative capacity of ATGL-KO mice, in vivo, with dynamic 31PMRS, simultaneously with force measurements.