Abstract #0268

Diffusion Measurements Reveal a Difference in Apparent Diffusion Coefficients of Intra- & Extramyocellular Lipids

Vaclav Brandejsky¹, Roland Kreis¹, Christine Sandra Bolliger², Chris Boesch¹

¹Dept. of Clinical Research, University of Bern , Bern, Switzerland; ²Dept. of Clinical Research, University of Bern, Bern, Switzerland

Intra- (IMCL) and extramyocellular (EMCL) lipids have been studied by diffusion weighted MRS, which is optimized to avoid motion- and vibration-related artifacts at large b-values. Results show differences between the diffusion properties of the EMCL/IMCL lipid pools in human muscle. The low apparent diffusion coefficient of IMCL can only be explained by restricted diffusion while EMCL seems to diffuse freely. The results indicate that in vivo droplet size measurements of IMCL using MRS might be possible.