Short Term Measurement Reproducibility of Perfusion Fraction (F), Pseudo-Diffusion Coefficient (D*) & Diffusion Coefficient (D) in Colorectal Liver Metastases Derived By Intravoxel Incoherent Motion Analysis of Respiratory-Triggered Diffusion-Weighted MR Imaging

Adrian Andreou¹, Matthew Orton², David J. Collins^1,2, Martin O. Leach², Dow-Mu Koh¹

Applying the principles of intravoxel incoherent motion (IVIM) allows quantitative parameters which reflect tissue microcapillary perfusion and tissue diffusivity to be derived. We evaluated the short term measurement reproducibility of the perfusion fraction (f), pseudo-diffusion (D*) and diffusion coefficients (D) of normal appearing liver and colorectal liver metastases in patients. We found that D showed good to moderate measurement reproducibility in liver and metastases. However, the reproducibility of f and D* was relatively poor but using a Bayesian method for analysis significantly improved the reproducibility of f and D* in metastases and D* in the liver.