Fast Macromolecular Proton Fraction Mapping From a Single Off-Resonance Magnetization Transfer Measurement

Vasily L. Yarnykh¹

This study demonstrates the feasibility of fast and accurate macromolecular proton fraction (MPF) mapping using only a single-offset MT-weighted image. This approach is the fastest to date quantitative MT (qMT) method, which requires no extra time compared to traditional magnetization transfer ratio (MTR) mapping, if a complementary T1 map is available. Since the proposed method rapidly determines MPF with high accuracy, it provides a viable alternative to both time-consuming multi-parameter qMT techniques and fast but poorly-interpretable MTR measurements.