Abstract #0189

Segmentation of Tumor Infiltrative & Vasogenic Edema in Brain Tumors using Voxel-Wise Analysis of 11C-Methinonine & FDG PET & its Comparison with Diffusion Tensor Imaging

Manabu Kinoshita¹, Testu Goto¹, Hideyuki Arita¹, Naoki Kagawa¹, Yasunori Fujimoto¹, Haruhiko Kishima¹, Yoichi Saitoh², Jun Hatazawa³, Naoya Hashimoto¹, Toshiki Yoshimine¹

¹Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; ²Neuromodulation & Neurosurgery, Center for Advanced Science & Innovation, Osaka University, Suita, Osaka, Japan; ³Nuclear Medicine & Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Use of DTI has been proposed for the detection of glioma cell invasion. However, other reports have questioned its value. We have been able to segment areas with and without tumor cell invasion in the T2-high intensity area in malignant gliomas using a voxel-wise analysis of 11C-methionine and FDG PET. We also showed the profile of FA and ADC does not differ between these two. Our results suggest the possibility of using voxel-wise analysis of 11C-methionine and FDG PET for tumor cell invasion in the T2-high intensity area in glioma patients and questioning the use of DTI for this purpose.