Abstract #0184

Detection of 2-Hydroxyglutarate in Mutant Brain Tumors In Vivo using Proton Magnetic Resonance Spectroscopy

Rajakumar Nagarajan¹, Michael Albert Thomas¹, Whitney B. Pope¹, Robert M. Prins², Neil Wilson¹, Noriko Salamon¹, Linda M. Liau²

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA; ²Neurosurgery, University of California Los Angeles

The mutation observed in the isocitrate dehydrogenase1 (IDH1) gene, which occurs in the majority of grade II and grade III gliomas and secondary glioblastomas shows significant elevation of 2-hydroxyglutarate (2HG) in the brain tumors. We have quantified 2HG in the brain tumor patients using proton (1H) MR spectra recorded on a 3T MRI/MRS scanner and post-processed by LC-model algorithm. In this study, we show increased 2HG in the mutant type compared to wild type tumors. 1H MRS enables a non-invasive measure of 2HG in gliomas, which may serve as a potential biomarker for monitoring patients with IDH1 mutant brain tumors.