Abstract #0140

In-Vivo Proton MR Spectroscopic Imaging of Glycine in Brain Tumors at 3.0 T

Sandeep Kumar Ganji¹, Ivan E. Dimitrov^1,2, Elizabeth A. Maher³, Changho Choi¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; ²Philips Medical Systems, Cleveland, OH, USA; ³Internal Medicine & Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Abnormality of glycine (Gly) concentrations has been reported in several brain disorders using single-voxel localized spectroscopic methods. Spectroscopic imaging of Gly in vivo is challenging due to its low concentrations and the spectral overlap, primarily with myo-inositol. We employed an optimized-TE PRESS-based chemical shift imaging method for glycine imaging. We present phantom validation of the technique and preliminary data from tumor patients together with single-voxel data for comparison. The concentration maps of metabolites are also presented.