Abstract #0050

A Novel Luminal Water Model for DCE MRI of Prostatic Tissues

Susan M. Noworolski^1,2, Galen D. Reed^1,2, John Kurhanewicz^{1, 2}

¹Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; ²Graduate Group in Bioengineering, University of California, San Francisco & Berkeley, San Francisco & Berkeley, CA, USA

It has been suggested that Gd-DTPA does not reach intact prostatic ducts. A novel pharmacokinetic model of the prostate incorporating Gd-inaccessible luminal water is presented. A feature of this Luminal Water model is that it allows for a slower washout, quite common in healthy and benign, glandular prostate tissues. Simulations and an example in vivo case demonstrate that the standard extended Tofts-Kermode model would greatly underestimate K^trans and Vees in glandular tissues (14% - 44% in cases shown). Incorporation of the Gd-inaccessible luminal water may yield parameters more accurately reflecting underlying tissue and has promise for aiding prostate tissue characterization.