Abstract #0047

Multiparametric 3T MR Imaging of Prostate Cancer: Histopathologic Correlation using Customized MRI-Based Specimen Molds

Baris Turkbey¹, Haresh Mani², Vijay Shah^3,4, Marcelino Bernardo^{3,
4}, Ardeshir Rastinehad⁵, Thomas Pohida⁶, Yuxi Pang⁷, Dagane Daar³, Compton Benjamin⁵, Yolanda McKinney¹, Joanna Shih⁸, Maria J. Merino², Peter A. Pinto⁵, Peter L. Choyke¹

¹Molecular Imaging Program, NCI, NIH, Bethesda, MD, USA; ²Laboratory of Pathology, NCI, NIH, USA; ³Molecular Imaging Program, NCI, NIH, USA; ⁴Imaging Physics, SAIC Frederick, Inc., NCI-Frederick; ⁵Urologic Oncology Branch, NCI, NIH, USA; ⁶Division of Computational Bioscience, Center for Information Technology, NIH, USA; ⁷Philips Healthcare, USA; ⁸Biometric Research Branch, NCI, NIH, USA

Multiparametric MRI has better sensitivity for detecting larger (> 5 mm in diameter) and more aggressive (Gleason score of > 7) tumors. The use of the mold enables more exact correlation between each MR parameter and the histopathologic specimen. The customized mold provided tissues blocks that had a one to one correspondence with the in vivo MR.