Abstract #0007

Ultra-High Resolution Functional MRI & Electrophysiology of the Rat Primary Somatosensory Cortex

Yen-Yu Ian Shih¹, You-Yin Chen², Hsin-Yi Lai², Timothy Q. Duong¹

¹Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; ²Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan

This study employed very high resolution CBV fMRI (40x40 m in-plane resolution) and multichannel field potential recording to investigate the neurovascular coupling within cortical laminae. This MRI resolution was achieved by using a small surface coil and an 11.7 T scanner. Graded forepaw electrical stimulation was employed to modulate layer-specific neuronal activities. Our results indicate that CBV responses and field potential changes at laminar resolution are not completely coupled.