Michaela Soellinger1, Christian Langkammer1,2,
Thomas Seifert-Held1, Nikolaus Krebs2, Monika Gloor3,
Eva Scheurer2, Klaus Scheffler3, Franz Fazekas1,
Stefan Ropele1
1Department of Neurology, Medical
University of Graz, Graz, Austria; 2Ludwig Boltzmann Institute for
Clinical-Forensic Imaging, Graz, Austria; 3Department of
Radiology, University Hospital Basel, Basel, Switzerland
A
crucial issue in determining quantitative magnetization transfer (qMT)
parameters using balanced steady state free precession (bSSFP) is the
estimation of the on-resonant singularity of the superlorentzian absorption
line shape G0. We present an empirical G0 calibration method for postmortem in-situ
brain scans at 3T using cross-linked BSA (bovine serum albumin) probes. For the investigated temperature range from
6-20C G0 resulted in 2.0*10-5. First qMT results of three postmortem in-situ
brain scans revealed decreased bound pool size ratios f in white matter
compared to in-vivo scans.