Jessy J. Mouannes1, Wanyong Shin2,
Saurabh Shah3, Anindya Sen4, Sameer Maheshwari1,
Timothy Carroll1,4
1Biomedical Engineering, Northwestern
University, Chicago, IL, United States; 2National Institute on
Drug Abuse, National Institute of Health, Baltimore, MD, United States; 3Siemens
Medical Solutions USA, Chicago, IL, United States; 4Radiology,
Northwestern University, Chicago, IL, United States
Self-CALibrated
Epi Perfusion Weighted Imaging (SCALE-PWI) MRI pulse sequence produces
quantitative cerebral perfusion images in a single MRI scan, using dynamic
susceptibility contrast (DSC) and T1 changes in normal white matter in
relation to changes in the blood pool
after contrast injection. A singular value decomposition algorithmic artifact
results in alternating signal intensity modulation in the reconstructed
quantitative perfusion maps of consecutive slices. A correction method to
eliminate this artifact is presented in this study at 1.5T. The results show
a significant effect of this correction on the resulting quantitative maps,
which become more accurate and suitable for clinical diagnosis.