Non-Rigid Motion Compensation in MR Prostate Perfusion Imaging

Gert Wollny¹, Isabel Casanova¹, Thomes Hambrock², Andres Santos¹, Maria Jesus Ledesma-Carbayo¹

Dynamic Contrast enhance MRI has been established as accurate method in detection and localization of prostate cancer. Time series of three-dimensional datasets of the prostate are acquired and used to obtain per-voxel signal-intensity vs. time curves. These are then used to differentiate cancerous from non-cancerous tissue. However, rectal peristalsis and patient movement may result in spatial-mismatching of the serial datasets and, therefore, incorrect enhancement curves. In this work, we present a method based on image registration to compensate for these movements, and validate the method by comparing pre-and postregistration intensity time curves to manually obtained ones.