Jamu K.
Alford1, Blaine A. Chronik1
1Physics and Astronomy, The University
of Western Ontario, London, ON, Canada
Delta
relaxation enhanced magnetic resonance (dreMR) is an emerging method for
performing molecular imaging, which utilizes a removable electromagnetic coil
to modify the strength of the main magnetic field during an MRI pulse
sequence. The purpose of this
field-cycling method is to acquire information about the binding state of
targeted contrast agents that is not obtainable with static-field MRI
methods. This work describes a method
for advancing dreMR from qualitative imaging to quantitative measurement of
contrast agent binding. By measuring
the concentration of bound agent, the corresponding concentration of the
target molecule can determined.