Sungheon Kim1, Lindsey DeCarlo2,
Gene Y. Cho1, Jens H. Jensen1, Daniel K. Sodickson1,
Silvia Formenti3, Robert J. Schneider2, Eric E. Sigmund1
1Center for Biomedical Imaging,
Radiology, New York University, New York, NY, United States; 2Microbiology,
New York University, New York, NY, United States; 3Radiation
Oncology, New York University, New York, NY, United States
This
study was to investigate the feasibility of using
Intra-Voxel-Incoherent-Motion (IVIM) diffusion weighted imaging (DWI) to
detect the early onset of tumor vascular normalization induced by an
antiangiogenic therapy. BALB/c mice with 4T1 tumor were scanned before and
after administration of Bevacizumab. The average ADC from the monoexponential
diffusion model did not change noticeably by post-treatment day 1. However,
the biexponential model was found to be adequate for more voxels in the tumor
and the product of perfusion fraction and pseudodiffusivity increased
substantially in one day, suggesting the feasibility of using IVIM-DWI for
early detection of vascular normalization.