Adriana-Teodora Perles-Barbacaru1,2,
Boudewijn Van der Sanden3, Rgine Farion1, Christoph
Segebarth1, Hana Lahrech1
1Functional and Metabolic Neuroimaging,
Grenoble Institute of Neuroscience, Grenoble, France; 2Caltech
Brain Imaging Center, Beckman Institute, Pasadena, CA, United States; 3Rayonnement
Synchrotron et Recherche Mdicale, Grenoble Institute of Neuroscience,
Grenoble, France
The
cerebral blood volume fraction (CBVf) quantification by MRI remains complex
in the tumor due to the contrast agent (CA) leakage through the blood brain
barrier. Gd-ACX (α-cyclodextrin complexed to gadolinium), a novel CA was
shown to remain in the vascular space in a C6 brain tumor model and was used for
CBVf mapping in microvasculature permeable for Gd-DOTA. Here, the use of
Gd-ACX for tumor CBVf quantification was validated using histological
vascular morphometry. After selecting the tumor vessels perfused by the
Hoechst dye, we found a quantitative equivalence for the CBVf obtained by MRI
and by vascular morphometry.