Radka Stoyanova1, Raj Rajpara1,
Elizabeth Bossart1, Victor Casillas2, Jill Palma1,
May Abdel-Wahab1, Alan Pollack1
1Radiation Oncology, University of
Miami, Miami, FL, United States; 2Diagnostic Radiology, University
of Miami, Miami, FL, United States
We
present analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for identification
of local recurrence of prostate cancer in men who underwent radical
prostatectomy and had a subsequent rising Prostate-Specific Antigen (PSA).
Our results indicate that we can detect abnormalities suggestive of residual
tumor in the prostate bed in nearly 75% of patients evaluated for radiation
therapy (RT). Because patients treated with salvage RT often develop a rising
PSA later and there is some evidence for a RT dose response, targeting of the
contrast-enhancing areas specifically may improve tumor control and limit
toxicity.