Moreno
Pasin1,2, Gloria Castellazzi1, Paul Summers2,
Roberto Di Filippi2, Luke Bonello2, Giuseppe Petralia2,
Massimo Bellomi2
1Struttura
Complessa di Radiologia/Diagnostica per immagini, Istituto Neurologico IRCCS-
Fondazione Casimiro Mondino, Pavia, Lombardia, Italy; 2Radiology,
Istituto Europeo di Oncologia, Milan, Lombardia, Italy
Variability
in two-point T1 estimation may lead to uncertainty in derived DCE parameters.
We examined the impact of T1 estimate noise on Ktrans, Kep, Ve, using two,
low flip angle scans combined with a single dynamic DCE measurement and ROI
definition in 9 rectal adrenocarcinoma patients at pre- and post- neoadjuvant
treatment examinations. Ktrans and Ve variations attributable to T1 estimates
were less than 5%, though variability in Ve may be exaggerated by peristaltic
motion. The variation in Kep was not value dependent. We recommend the use of
an aniperistaltic agent for rectal DCE to reduce variation in Ve.