Abstract #4754

Correlation Between Estrogen Receptor Positive (ER+) and Estrogen Receptor Negative (ER-) Status with TCho Concentration and Tumor Volume in Breast Cancer Patients.

Naranamangalam R. Jagannathan¹, Rani G. Sah¹, Uma Sharma¹, Rajinder Parshad²

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India

The tCho concentration and tumor volume were calculated using in-vivo MRS and MRI in estrogen positive and negative patients (n=46) with confirmed invasive ductal carcinoma at 1.5 T. The tumor volume for the estrogen positive patients was (33.57 45.7) significantly higher (p=0.03) compared to estrogen negative patients (67.2 60.8). However, the tCho concentration was similar in estrogen positive (4.2 2.3 mmol/kg) and estrogen negative patients (4.1 3.5) mmol/kg. The increase in the tumor volume may be attributed to the higher microvessels density in ER negative cancer patients.