Shutter-Speed Model Dynamic Contrast-Enhanced MRI to Reduce Unnecessary Surgeries of Atypical Breast Lesions: A Preliminary Study

Luminita Alina Tudorica¹, Stephanie Hemmingson¹, Karen Oh¹, Arpana Naik¹, Sunitha Thakur², Elizabeth A. Morris², Mark Kettler¹, Ian J. Tagge¹, Jason A. Koutcher², Charles S. Springer¹, Wei Huang¹

Three of 28 core needle biopsy-proven high-risk atypical breast lesions were upgraded to malignancies following surgical excisions as standard care. Correlations with pre-biopsy quantitative DCE-MRI results show that the Shutter-Speed Model (SSM) analyses of DCE-MRI data discriminate the atypical lesions between those completely benign and those containing malignancies with high accuracy. SSM DCE-MRI can potentially be used to reduce unnecessary surgeries of atypical lesions.