Hersh Chandarana1, Vivian S. Lee1,
Elizabeth Hecht1,2, Bachir Taouli1,3, Eric E. Sigmund1
1Radiology, NYU Langone Medical Center,
New York, NY, United States; 2Radiology, University of
Pennsylvania, United States; 3Radiology, Mount Sinai Medical
Center, New York, NY, United States
Movement
of blood in microvasculature can be modeled as pseudo-diffusion also known as
intravoxel incoherent motion. Perfusion effect can be separated if diffusion
imaging is performed with low and high b values. The purpose of our study was
to calculate perfusion fraction (fp) and tissue diffusivity (Dt) parameters
obtained with biexponential analysis of multi-b DWI and determine if these
parameters can distinguish enhancing from non-enhancing renal lesions. fp was
higher and Dt lower in enhancing renal lesions; both these parameters had
higher accuracy in detection of enhancing renal lesion compared to apparent
diffusion coefficient (ADC) obtained with monoexponential fit.