Abstract #4678

Renal Perfusion and Oxygen Bioavailability in Swine: Comparing Isoflurane to Propofol

Logan Dance¹, Andrew Wentland², Nathan Artz², Sean Fain^1,2, Arjang Djamali³, Elizabeth Sadowski¹

¹Radiology, University of Wisconsin, Madison, WI, United States; ²Medical Physics, University of Wisconsin, Madison, WI, United States; ³Nephrology, University of Wisconsin, Madison, WI, United States

Blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) MR imaging can analyze the drug-specific effects of anesthetics on regional perfusion. Conflicting data currently exists regarding isoflurane's effect on renal perfusion. Using a swine model, we found that isoflurane decreased renal perfusion (ASL; microspheres) and renal oxygen bioavailability (BOLD MR) when compared to propofol. Isoflurane also caused a significant increase in heart rate and decrease in mean arterial pressure, compared to propofol. These effects should be considered when designing kidney perfusion studies.