Jan Weis1, Kathrine Bjersand2,
Anna Karin Wikstrm2, Mats Olovsson2, Johan Wikstrm3
1Department of Oncology, Radiology and
Clinical Immunology, Uppsala University, Uppsala, Sweden; 2Department
of Women's and Children's Health, Uppsala University, Uppsala, Sweden; 3Department
of Oncology, Radiology and Clinical Immunology, Uppsala University , Uppsala,
Sweden
31P
image-selected in vivo spectroscopy (ISIS) with proton decoupling and nuclear
Overhauser effect enhancement was used for measurement the spectra of
placental tissue in vivo. Major metabolites of normal human placenta and
placentas from women with preeclampsia were quantified. Our results
demonstrate that the 31P MRS is able to measure spectra of the placenta with
acceptable quality and measurement time. 31P MRS is a promising tool to
detect in vivo changes of human placental metabolites.