Evaluation of Uptake and Excretion of Gd-EOB-DTPA in Normal and Cirrhotic Livers

Tsutomu Tamada¹, Atsushi Higaki¹, Akihiko Kanki¹, Tomohiro Sato¹, Kazuya Yasokawa¹, Katsuyoshi Ito¹

We assessed differences in enhancement effects of liver parenchyma and activity of biliary and renal excretion between normal and cirrhotic livers on Gd-EOB-DTPA-enhanced MR imaging. It will be important to know that hepatic enhancement effects in the HP are decreased in patients with severe cirrhosis, probably due to impaired uptake of Gd-EOB-DTPA by hepatocytes, and biliary excretion is impaired in cirrhotic livers in comparison with normal livers while renal excretion of Gd-EOB-DPTA can be increased, probably due to the compensatory mechanism.