Idit Matot1, Miriam Katz2, Orit
Pappo3, Nathalie Corchia4, Gregory Barshtein5,
Shaul Yedgar5, Rinat Abramovitch, 6
1Department of Anesthesiology &
Intensive Care, Tel Aviv, Sourasky Medical Center, Tel Aviv, Israel; 2Department
of Anesthesiology, Rabin Medical Center, Petach Tiqva, Israel; 3Pathology,
Hadassah Hebrew University Medical Center, Jerusalem, Israel; 4he
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical
Center, Jerusalem, Israel; 5Department of Biochemistry, Hebrew
University, Jerusalem, Israel; 6MRI/MRS lab HBRC, Hadassah Hebrew
University Medical Center, Jerusalem, Israel
Concerns
have recently been raised about the safety of transfusing stored-blood.
Several studies have suggested that the risk of complications increases when
transfused blood has been stored for long period. The liver is a target for
injury in low flow states associated with trauma and hemorrhage. We studied
the effect of blood resuscitation (fresh vs. Stored-blood) on liver injury.
In rats, transfusion of blood stored longer than 4 days increased liver
injury. This was associated with significant changes in the viscoelastic
characteristics of the stored-blood and unrelated to the
oxygen-carrying-capacity, cytokines in the stored-blood or the
RBC/endothelial cells adherence properties.