Sungheon Kim1, Linda Moy1,
Malcolm C. Pike2, Anne Zeleniuch-Jacquotte3, Tess
Clendenen4
1Center for Biomedical Imaging,
Radiology, NYU School of Medicine, New York, NY, United States; 2Preventive
Medicine, USC Keck School of Medicine, Los Angeles, CA, United States; 3Environmental
Medicine, NYU School of Medicine, New York, NY, United States; 4Epidemiology,
NYU School of Medicine, New York, NY, United States
The
purpose of this study was to develop a multiparametric MRI method to
investigate magnitude and timing of various breast changes during the
menstrual cycle. Five healthy premenopausal women were scanned once a week
for four weeks. T2, ADC, and magnetization transfer rate were measured. T2
gradually increased throughout the cycle and was 5% higher in the menstrual
phase than the follicular phase. In contrast, the median ADC was highest in
the luteal phase (15% greater than the follicular phase) and began to decline
during menses. The MTR was about 4% lower in the menstrual phase than the
follicular phase.