April M. Chow1,2, Iris Y. Zhou1,2,
Shu Juan Fan1,2, Kannie W.Y. Chan1,2, Kevin C. Chan1,2,
Ed X. Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR,
China; 2Department of Electrical and Electronic Engineering, The
University of Hong Kong, Pokfulam, Hong Kong SAR, China
Neonatal
hypoxic-ischemic (HI) cerebral injury is major cause of permanent damage to
neuronal cells. The neonatal brain undergoes regenerative processes late
after HI injury. While 1H MRS has been employed to investigate
metabolic changes during acute-phase of HI injury, roles of major
neurochemicals as markers for neurodegeneration and neuroprotection at late
stage are also important for studying the neurophysiological changes. In this
study, we showed that alteration in the metabolism at late stage in cortical
and subcortical structures is associated with neonatal HI cerebral injury.
This may provide insights into the plastic changes and adaptive modifications
within brain following injury.