Jonathan D. Thiessen1, Yanbo Zhang2,
Handi Zhang2, Lingyan Wang2, Richard Buist3,
Jiming Kong4, Xin-Min Li2, Melanie Martin1,5
1Physics and Astronomy, University of
Manitoba, Winnipeg, Manitoba, Canada; 2Psychiatry, University of
Manitoba; 3Radiology, University of Manitoba; 4Human
Anatomy and Cell Science, University of Manitoba; 5Physics,
University of Winnipeg
Magnetic
resonance imaging methods capable of quantifying changes due to demyelination
can improve both the diagnosis and understanding of white matter diseases
such as multiple sclerosis. T2-weighted
and magnetization transfer images (MTI) were acquired weekly in control (n=4)
and cuprizone-fed mice (n=4) from 2 to 6 weeks of treatment. Diffusion tensor imaging, quantitative MTI,
high-resolution T2-weighted imaging, and histopathology were used
to analyze ex vivo tissue. All in
vivo methods showed significant differences longitudinally in the corpus
callosum of the cuprizone-fed mouse.
All in vivo and ex vivo methods showed significant differences in the
corpus callosum between groups.