Jeff F. Dunn1,2, Thorarin A. Bjarnason3,
Tonima Ali3, Ying Wu1,2, Cheryl R. McCreary1,2,
Ross J. Mitchell, 2,4
1Hotchkiss Brain Institute, University
of Calgary, Calgary, Alberta, Canada; 2Department of Radiology,
University of Calgary, Calgary, Alberta, Canada; 3Biomedical
Engineering, University of Calgary; 4Department of Clinical
Neurosciences, University of Calgary, Calgary, Alberta, Canada
Quantitative
T2 (qT2) has been used to identify a range of pathophysiology in brain
including multiple sclerosis. We have extended the application of qT2 to that
of assessing heterogeneity of stroke within an experimental infarct in a rat
brain. We have applied a recently published voxel-based approach, which
allows for assessment of heterogeneity of T2 components. It was determined
that the proportion of the total T2 which relates to the 50-60ms range
results in visualization of the periphery of the infarct. This type of
approach may be useful in identification of the ischemic penumbra.