Usama Abo-Ramadan1,2, Miia pitkonen2,
Eric Pedrono2, Ivan Marinkovic1,2, Aysan Durukan1,2,
Turgut Tatlisumak1,2
1Dept of Neurology, Helsinki Uiversity
Central Hospital, Helsinki, Finland; 2Experimental MRI Laboratory,
Biomedicum Helsinki, Helsinki, Finland
We
measure the DT indices changes in stroke model from the hyperacute to chronic
phase. Rats are sub-jected to focal cerebral ischemia for 90 minutes followed by reperfusion. DT
imaging studies were performed with a
4.7 T scanner. Significant DT indices changes were related to the evolution
of the transient MCAO. DTI indices may allow separate evaluation of the
treatment response of white and gray matter to neuroprotective therapy. DTI
analysis of directional diffusivities could provide additional information to
FA and MD, and may reflect more specifically the histological changes of
reduced mye-lination and axonal injury.