Mario
Quarantelli1, Olga Palladino2, Anna Prinster1,3,
Vittorio Schiavone2, Barbara Carotenuto4, Arturo
Brunetti4, Gianluca Ventrella2, Angela Marsili1,
Andrea De Bartolomeis2, Marco Salvatore4
1Biostructure and Bioimaging Institute,
National Research Council, Naples, Italy; 2Institute of
Psychiatry, University Federico II, Naples, Italy; 3 S.D.N.
Foundation, Naples, Italy; 4Department of Biomorphological and
Functional Sciences, University Federico II, Naples, Italy
We
assessed structural cerebral differences between 16 normal volunteers (NV),
16 Responder (R-SC), and 19 Non-Responder (NR-SC) schizophrenia patients.
Segmented T1-weighted volumes were analyzed voxel-wise to assess local
differences in gray matter volume between the three groups, using permutation
tests implemented in the CamBA software. Main clusters of significant GM
differences among the three groups emerged in bilateral frontal cortices,
right insula and right medial temporal lobe, differences being mainly due to
reduced GM volumes in NR-SC, as compared to both NV and R-SC, suggesting that
differences between NV an SC may be mainly driven by NR-SC patients.