Tian Liu1,2, Jing Liu2, Ludovic
de Rochefort3, James Ledoux2, Qing Zhang4,
Martin R. Prince2, Jianlin Wu4, Yi Wang1
1Biomedical Engineering, Cornell
University, New York, NY, United States; 2Radiology, Weill Cornell
Medical College, New York, NY, United States; 3MIRCen, I2BM, DSV,
CEA, Fontenay-aux-Roses, France; 4Radiology, The 1st Hospital of
Dalian Medical University, Dalian, Liaoning, China
Increasing
iron deposition with increasing age has been confirmed in postmortem studies
and observed in in vivo MRI. In this 100 volunteer study, we specifically
measured susceptibility in putamen, and converted it to Fe3+ concentration. A
strong linear correlation was obtained between susceptibility and age. The
iron concentration agreed well with postmortem results.