Memi Watanabe1, Noreen Ward1, Al
Ozonoff2, Steven Kussman1, Koji Tanabe1,
Kaan Erbay1, Naoko Saito1, Hernan Jara1,3,
Osamu Sakai1
1Department of Radiology, Boston
Medical Center, Boston University School of Medicine, Boston, MA, United
States; 2Department of Biostatistics, Boston University School of
Public Health, Boston, MA, United States; 3Department of
Biomedical Engineering, Boston University, Boston, MA, United States
Purpose:
To study age dependencies of ADC histogram and impact of brain abnormalities
on ADC in a large and wide age ranged population. Methods: Brain data of 667
subjects (2 days-93.8 years) were obtained by DW-SE-sshEPI and ADC histograms
of the whole brain were generated. The subjects were divided into normal and
abnormal groups by MR findings and clinical histories. Results: The abnormal
group showed higher ADC peak values compared with the normal. Conclusion: The
aging patterns of ADC peak values of normal and abnormal brain groups have
been demonstrated in a large and wide age ranged population.