Byeong-Yeul Lee1, James R. Connor2,
Qing X. Yang, 1,3
1Bioengineering, Penn State Hershye Medical
Center, Hershey, PA, United States; 2Neurosurgery, Penn State
Hershye Medical Center, Hershey, PA, United States; 3Radiology,
Penn State Hershye Medical Center, Hershey, PA, United States
Restless
leg syndrome (RLS) is a sensory-motor disorder characterized by
uncontrollable urges to move the legs, causing chronic sleep disturbances.
Brain iron deficiency has been considered as an important contributing factor
to RLS. In this study, we applied
voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based
morphometry (VBM) for morphological study respectively to a same study
cohort, aiming to determine the impact of iron deficiency on brain
morphology. Our results revealed a striking association of local T2 change
with brain atrophy.