Daniel J. Tozer1, Abdulgabbar Hamid1,
Declan T. Chard1, David H. Miller1, Alan J. Thompson2
1NMR Unit, Department of
Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Brain
Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
It
is known that the normal appearing tissue of subjects with multiple sclerosis
is abnormal, but not whether this is linked to focal white matter (WM)
lesions or more widespread. This work investigates the tissue surrounding
lesions for a variety of MRI parameters and compares them to the lesion and
distant WM. Up to 9 pixel thick layers were extracted for MTR, T1 and T2
maps. It was found that much of this tissue is different to WM and the
lesion. Hypointense and isointense lesions (on T1 weighted images) also
behaved differently suggesting different pathological processes occurring at
different times.