Abstract #4328

A Five-Year Serial Longitudinal Study of Deep Gray Matter Atrophy in Patients with Multiple Sclerosis

Robert Zivadinov¹, Dana Horakova², Michael G. Dwyer³, Deepa Ramasamy³, Eva Havrdova², Zdenek Seidl⁴, Ondrej Dolezal³, Sara Hussein³, Ellen Carl³, Manuela Vaneckova⁴, Niels Bergsland³

¹Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States; ²Charles University, Department of Neurology, Prague, Czech Republic; ³University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; ⁴Charles University, Department of Radiology, Prague, Czech Republic

To compare the evolution of deep gray matter (DGM) atrophy in early relapsing-remitting (RR) multiple sclerosis (MS) patients and in normal controls (NC) over 2 years. To investigate the extent of DGM atrophy progression in MS patients over 5 years.