Abstract #4326

Deep Gray Matter Atrophy in a Large Sample of Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis Patients

Niels Bergsland¹, Michael G. Dwyer¹, Dana Horakova², Ondrej Dolezal¹, Zdenek Seidl³, Manuela Vaneckova³, Eva Havrdova², Robert Zivadinov⁴

¹University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; ²Charles University, Department of Neurology, Prague, Czech Republic; ³Charles University, Department of Radiology, Prague, Czech Republic; ⁴Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States

To quantify deep gray matter (DGM) atrophy in a large sample of clinically isolated syndrome (CIS) patients, early relapsing-remitting (RR) multiple sclerosis (MS) patients, and healthy controls (HC). To investigate the relationship between DGM atrophy and disability in CIS patients.