Maxim Bester1,2, Jens H. Jensen1,
Ali Tabesh1, Hina Jaggi1, Cathy Hu1, Joseph
Herbert3, Robert I. Grossman1, Matilde Inglese,
3,4
1Radiology, New York University, New
York, NY, United States; 2Neuroradiology, Eppendorf-Hamburg
University, Hamburg, Germany; 3Neurology, New York University, New
York, NY, United States; 4Radiology , New York University, New
York, NY, United States
Diffusion
tensor imaging (DTI) is useful to assess subtle pathology in normal-appearing
white matter of multiple sclerosis (MS) patients. Diffusional kurtosis
imaging (DKI) measures the non-Gaussian water diffusion and mean kurtosis
(MK) is sensitive to structural changes in isotropic tissue such as gray
matter (GM). The aims of this study were to assess GM in MS patients using
DKI and DTI and to investigate the relationship between GM MK and white
matter injury. Differences from controls were observed in both GM MK and DTI
metrics suggesting that DKI can provide additional complementary information
about brain tissue microstructure