Abstract #4312

Multimodal High Resolution Magnetization Transfer and T1mapping in NAWM of Patients with Clinically Isolated Syndrome

Ali Al-Radaideh¹, Olivier Mougin¹, Su-Yin Lim², Christopher Tench², Cris Constantinescu², Penny Gowland¹

¹Sir Peter Mansfield MR Centre, The University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; ²Clinical Neurology, The University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Multiple Sclerosis (MS) is known to reduce magnetization transfer ratio (MTR)and increase the longitudinal relaxation time (T1) in the white matter (WM). Here, we measure the distribution of MTR and T1 values in normal appearing white matter (NAWM) at 7T and high spatial resolution, comparing CIS patients with healthy controls.