Heisoog Kim1,2, Ciprian Catana1,
Grace Kim1, Ovidiu C. Andronesi1, Dominique L. Jennings1,
Divya S. Bolar1,3, Elizabeth R. Gerstner4, Tracy T.
Batchelor4, Rakesh K. Jain5, Alma Gregory Sorensen1
1A.A.Martinos center, Massachusetts
General Hospotal, Charlestown, MA, United States; 2NSE/HST,
Massachusetts Institute of Technology, Cambridge, MA, United States; 3EECS/HST,
Massachusetts Institute of Technology, Cambridge, MA, United States; 4Neurology,
Massachusetts General Hospotal, Boston, MA, United States; 5Radiology,
Massachusetts General Hospotal, Boston, MA, United States
This
study quantitatively investigated BOLD responses to pure oxygen in
glioblastoma (GBM) throughout the course of the treatment with chemoradiation
and an anti-angiogenic drug. BOLD signal changes dropped significantly at the
beginning of the treatment in tumor and gradually recovered afterwards.
Conversely, in contralateral normal tissue a slight increase was observed at
the early time points. Interestingly, no difference was observed between
values in both regions after 35 days. Our preliminary findings suggest that
assessing the oxygenation status before and after treatment might be useful
for both prognostic and diagnostic assessment in GBM patients.