Differentiation Between Glioblastomas, Brain Metastases and Primary Cerebral Lymphomas Using Diffusion and Perfusion Weighted Imaging

Sumei Wang¹, Sungheon Kim², Sanjeev Chawla¹, Ronald L. Wolf¹, David Knipp¹, Arastoo Vossough¹, Donald M. ORourke³, Kevin D. Judy³, Elias R. Melhem¹, Harish Poptani¹

Twenty-six glioblastomas, 25 brain metastases and 16 cerebral lymphomas underwent DTI and DSC studies. FA, ADC, CL, CP, CS and rCBV were measured from the enhancing part of the tumor. Elevated FA, CL, CP and decreased CS were observed in glioblastomas compared with both metastases and lymphomas, whereas ADC and rCBV values from glioblastomas were significantly higher than lymphomas. FA and ADC was the best predictor for differentiation of glioblastomas from non-glioblastomas, whereas ADC, CS and rCBV were the best model for distinguishing lymphomas from metastases. Our study indicates that DTI metrics along with rCBV measurement may be helpful in tumor classification.