F Kara1,
N Braakman1, M A. van Buchem2, H JM de Groot1,
R Schliebs3, A Alia1
1Leiden Institute
of Chemistry, Leiden University, Leiden, Netherlands; 2Department
of Radiology, Leiden University Medical Center, Leiden, Netherlands; 3Department
of Neurochemistry, University of Leipzig, Leiden, Netherlands
In
this study we longitudinally monitored, the blood flow alterations in TG2576
mouse model of Alzheimer's disease using MR angiography. Blood flow
alterations were clearly increased in transgenic mice over time. Flow defects
in middle cerebral artery were seen already at the age of 8 month when there
was no cerebral amyloid angiopathy (CAA) was observed. In anterior cerebral
artery the flow alterations were visible at the age of 19 months and were
correlated with CAA as well as with high plaque deposition in the brain
tissues. Our results show that blood flow defects are present long before
vascular deposition of Aβ takes place in this mouse model.