Mona Adel Mohamed1,2, Peter B. Barker1,2,
Richard L. Skolasky3, Richard T. Moxley3, Martin G.
Pomper1, Ned C. Sacktor3
1Radiology, Johns Hopkins University
School of Medicine, Baltimore, MD, United States; 2Kennedy Krieger
Institute, FM Kirby Center for Functional Brain Imaging, Baltimore, MD,
United States; 3Neurology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
The
major finding of the current study is that brain MRS performed at 3T reveals
decreased levels of Glx in the frontal white matter (FWM) of patients with
HIV-associated dementia (HAD) compared to those without dementia. FWM Glx
decreases were also associated with poorer cognitive function, specifically
impaired executive and fine motor functioning in HAD. 3T MRS measurements of
Glx may be a useful indicator of neuronal loss or dysfunction in patients
with HIV infection.