Feng Feng1, Hui You1, Han Wang2,
Fuling Zheng1, Chunling Meng1, Jue Wang3,
Yufeng Zang3
1Radiology, Peking Union Medical
College Hospital, Beijing, China; 2Neurology, Peking Union Medical
College Hospital, Beijing, China; 3State Key Laboratory of
Cognitive Neuroscience and Learning, Beijing Normal University, Beijing,
China
MSA
is mainly a sporadic neurodegenerative disease. Besides abnormalities of
nigrostriatal pathway, the typical pathological findings were also described
in primary motor and supplementary motor cortices. We hypothesize that there
is associated disturbance of functional connectivity of the motor cortex in
MSA patients. To test the hypothesis, resting-state functional MRI was used
to measure the coherent spontaneous fluctuations in the blood oxygenation
levelCdependent signal. Our results showed regional homogeneity changes in
left precentral gyrus, right precuneus, supramarginal gyrus and middle
frontal gyrus, indicating functional connectivity disturbance of
motor-related circuits and left-sided predominance of primary motor cortex
involvement.