Jonghoon Choi1,2, Kyobum Kim3,
Taeho Kim4, Taeghwan Hyeon4, Mike T. McMahon1,
Jeff WM Bulte1, John P. Fisher3,5, Assaf A. Gilad1
1Radiology, Johns Hopkins University
School of Medicine, Baltimore, MD, United States; 2Biochemical
Science, National Institute of Standard and Technology, Gaithersburg, MD,
United States; 3Chemical and Biomolecular Engineering, University
of Maryland, College Park, MD, United States; 4Chemical
Engineering, Seoul National University, Seoul, Korea, Republic of; 5Fischell
Department of Bioengineering, University of Maryland, College Park, MD,
United States
Three-dimensional
PPF (poly(propylene fumarate)) scaffolds carrying cancer drug-coated
nanoparticles showed controlled release of drug nanoparticles and bimodal
imaging (fluorescence and magnetic resonance) capabilities. This novel
biopolymer matrix could be used for many biomedical applications, including
MR-guided implantation, as a drug-carrying vehicle, and as a tumor treatment
because of the persistent release of drugs in the vicinity of a malignancy.