Giuseppe
Digilio1, Valeria Menchise2, Eliana Gianolio3,
Franco Fedeli3, Concetta Gringeri1, Roberta Napolitano3,
Carla Carrera3, Valeria Catanzaro3, Silvio Aime3
1DISAV, University of Eastern Piedmont,
Alessandria, AL, Italy; 2Institute for Bioimages and
Biostructures, CNR, Naples, Italy; 3Department of Chemistry IFM,
University of Turin, Turin, Italy
Exofacial
protein thiols exposed on the cell surface are responsive to the redox state
of the extracellular milieu. They can be exploited as anchorage points for
suitably designed Gd-based MRI probes, allowing for the visualization of
hypoxic tumor regions.