Yi-Cheng Lee1, Der-Yow Chen2,
Stephen J. Dodd2, Nadia Bouraoud2, Alan P. Koretsky2,
Kannan M. Krishnan1
1MSE, University of Washington,
Seattle, WA, United States; 2NINDS, National Institutes of Health,
Bethesda, MD, United States
Manganese
based nanoparticles have potential as agents that can be
"activated" when taken into cells. It would be advantageous to be
able to control the rate of dissolution of Mn based nanoparticles to control
T1 contrast signals, in vivo with time. To this end, five
different coatings on MnO nanocrystals have been tested to study the release
rate of the Mn2+ ions and change in relaxivity at pH 7 compared to
pH 5. The MnO@SiO2 particles show the best potential for delaying
the release of MRI contrast until specific biological processes have
occurred, such as endocytosis.