Detection of Spontaneously Occuring Amyloid Plaques in a Primate Model of Alzheimer's Disease

Anne Bertrand¹, Adrien Pasquier¹, Alexandra Petiet^1,2, Christopher Wiggins², Sebastien Meriaux², Audrey Kraska¹, Olene Dorieux^1,3, Nelly Joseph-Mathurin¹, Philippe Hantraye¹, Fabienne Aujard³, Nadine Mestre-Frances⁴, Marc Dhenain^1,2

Amyloid deposits are one of the characteristic lesions of Alzheimer's disease. Their sizes range from 50 m to 200 m. These lesions can be detected in transgenic mouse model of Alzheimer's disease by MRI, however, amyloid deposits in mice are very different than those occurring spontaneously in aged primates or humans with Alzheimer's disease. Here, we show that a protocol based on the staining of amyloid plaques with a non targeted Gadolinium contrast agent allows to detect spontaneously occurring amyloid plaques in aged mouse lemur Primates.