In Vivo MRI Multicontrast Kinetic Analysis of the Uptake and Intracellular Trafficking of Paramagnetically Labeled Liposomes

Daniela Delli Castelli¹, Enzo Terreno¹, Walter Dastr¹, Evelina Cittadino¹, Francesco Mainini¹, Elena Torres¹, Michela Spadaro¹, Silvio Aime¹

The multi-contrast ability of paramagnetically loaded liposomes have been exploited to get a better understanding of their uptake and intracellular trafficking in vivo in a tumor environment.In order to account for the observed MRI data, a kinetic model able to describe the underlying biological processes has been developed. The fit of the data provides a rough estimate of the kinetic constants for each process considered in the model.