MR-Guided Trans-Perineal Cryoablation of Locally Recurrent Prostate Adenocarcinoma Following Radical Prostatectomy

David Arthur Woodrum¹, Lance Mynderse², Akira Kawashima¹, Krzysztof Gorny¹, Thomas Atwell¹, Fred Mcphail², Bradley Bolster³, Wesley Gilson³, Kimberly Amrami¹, Haraldur Bjarnason¹, Matthew Callstrom¹

Prostate cancer recurrence after definitive therapy can be as high as 25% after 15 years. Detection of these recurrences can be achieved using serial PSA coupled with dynamic contrast enhanced (DCE) MRI. Our hypothesis is MR-guided cryoablation can be used in the setting of prostate bed PAC recurrence to perform a precise image-guided focal ablation. Two patients with prior RRP and dynamic contrast enhancement(DCE) MRI abnormalities in the prostate bed were treated using MR-guided cryoablation. Both patients with recurrent prostate cancer in the prostate bed were successfully treated with MR-guided cryoablation. Immediate post-ablation DCE MRI demonstrated no definite residual tumor.